Article
Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils.
Infection and immunity - 1 Jul 1994
Papp-Szabò E, Firtel M, Josephy P D
Abstract excerpt
The respiratory burst of neutrophils is believed to kill bacteria by generating oxidative species, such as superoxide anion, hydrogen peroxide, and oxidized halogen species. The oxyR gene of Salmonella typhimurium controls a regulon induced by oxidative stress, such as exposure to hydrogen peroxide. Some researchers have suggested that oxyR may play a key role in bacterial survival following phagocytosis. We have...
Topics
- Bacterial Proteins
- Cell Movement
- DNA-Binding Proteins
- Humans
- Mutation
- Neutrophils
- Peroxidases
- Phagocytosis
- Regulon
- Repressor Proteins
- Salmonella typhimurium
- Transcription Factors