Article
OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms.
Molecular microbiology - 1 Dec 2008
Ieva Raffaele, Roncarati Davide, Metruccio Matteo M E, Seib Kate L, Scarlato Vincenzo, Delany Isabel
Abstract excerpt
Mechanisms for coping with oxidative stress (OS) are crucial for the survival of pathogenic Neisseria spp. in the human host. In this study we investigate the mechanism by which OxyR finely regulates the catalase gene (kat) in Neisseria meningitidis. Detailed transcriptional analyses show that catalase is transcribed from a single promoter that is induced by H(2)O(2) in an OxyR-dependent manner and two key...
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