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Article

Responses to reactive oxygen intermediates and virulence of Salmonella typhimurium.

Microbes and infection - 1 May 2003

Janssen Riny, van der Straaten Tahar, van Diepen Angela, van Dissel Jaap T

Abstract excerpt

Salmonella typhimurium is an intracellular pathogen that can survive and replicate in macrophages. One of the host defense mechanisms that S. typhimurium encounters upon infection is superoxide produced by the phagocytes' NADPH-oxidase. Salmonella has evolved numerous ways of coping with superoxide in the extracellular environment. In addition, Salmonella has to defend itself against superoxide produced as a...

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PMID: 12758282
DOI: 10.1016/s1286-4579(03)00069-8

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