Functional significance of different human CYP1A1 genotypes.

doi:10.1093/carcin/15.12.2961

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Article

Functional significance of different human CYP1A1 genotypes.

Carcinogenesis - 1 Dec 1994

Crofts F, Taioli E, Trachman J, Cosma G N, Currie D, Toniolo P, Garte S J

Abstract excerpt

At least two different polymorphisms in the human CYP1A1 gene have been associated with an increased risk for tobacco-related lung cancer; however, the functional significance of these polymorphisms has not been determined. We measured CYP1A1 genotypes, gene expression levels and enzymatic activi...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cytochrome P-450 Enzyme System
Enzyme Induction
Exons
Female
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms
Lymphocyte Activation
Male
Middle Aged
Molecular Sequence Data
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Racial Groups

Source

Open in PubMed

Identifiers

PMID: 8001264
DOI: 10.1093/carcin/15.12.2961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8001264-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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