Article
Radical differences in CYP1A1 genotype and function.
Toxicology letters - 1 May 1995
Taioli E, Crofts F, Trachman J, Bayo S, Toniolo P, Garte S J
Abstract excerpt
The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism. No concordance was observed in Africans or African-Americans between any of the...
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