Article
Human cytochrome P450IIE1 gene: DraI polymorphism and susceptibility to cancer.
The Tohoku journal of experimental medicine - 1 Oct 1992
Uematsu F, Kikuchi H, Motomiya M, Abe T, Ishioka C, Kanamaru R, Sagami I, Watanabe M
Abstract excerpt
Human cytochrome P450IIE1 (CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphisms among lung cancer patients (n...
Topics
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Digestive System Neoplasms
- Disease Susceptibility
- Genotype
- Humans
- Lung Neoplasms
- Oxidoreductases, N-Demethylating
- Polymorphism, Restriction Fragment Length