Article
Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease.
Pharmacogenetics - 1 Jan 1995
Kato S, Onda M, Matsukura N, Tokunaga A, Tajiri T, Kim D Y, Tsuruta H, Matsuda N, Yamashita K, Shields P G
Abstract excerpt
Cytochrome P4502E1 (CYP2E1) activates carcinogenic N-nitrosamines, benzene, urethane and other low molecular weight compounds. This enzyme is also inducible by ethanol, and metabolizes alcohol. A restriction fragment length polymorphism (RFLP) using the Rsa I restriction enzyme has been identifie...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- DNA Primers
- Female
- Gene Expression Regulation, Enzymologic
- Genetic Carrier Screening
- Genotype
- Homozygote
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Male
- Molecular Sequence Data