Article
Identification of an amino acid change that affects N protein function in vesicular stomatitis virus.
The Journal of general virology - 1 Dec 1994
Nickels M S, Hunt D M
Abstract excerpt
TsW16B is a temperature-sensitive mutant of vesicular stomatitis virus. Others have shown that it is temperature-sensitive for replication in vivo and for transcription in vitro and that these phenotypes are probably due to mutation of the N (nucleocapsid) gene. Five independent revertants were isolated from tsW16B based on their ability to grow at 39 degrees C. The thermosensitivity of in vitro transcription by...
Topics
- Animals
- Capsid
- Cell Line
- Cricetinae
- DNA Mutational Analysis
- Genes, Viral
- L Cells
- Mice
- Molecular Sequence Data
- Phenotype
- Phosphoproteins
- Point Mutation