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Article

Amino acid changes in the L polymerase protein of vesicular stomatitis virus which confer aberrant polyadenylation and temperature-sensitive phenotypes.

Virology - 1 Apr 1993

Hunt D M, Hutchinson K L

Abstract excerpt

TsG16(I) is a temperature-sensitive mutant of vesicular stomatitis virus. In vitro, at the permissive temperature (31 degrees), it makes long poly(A) tracts, shows a larger increase in polyadenylation in the presence of S-adenosyl-homocysteine than its parental wt(Glasgow) virus, and makes an excess of polycistronic mRNA. In vitro transcription is also more thermosensitive than that of wt virus. Previous work...

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Identifiers

PMID: 8384756
DOI: 10.1006/viro.1993.1187

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Amino acid changes in the L polymerase protein of vesicular stomatitis virus which confer aberrant polyadenylation and temperature-sensitive phenotypes.PMID 8384756Read ↗

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