Article
Receptor binding and signal transduction are dissociable functions requiring different sites on follicle-stimulating hormone.
Endocrinology - 1 Dec 1994
Valove F M, Finch C, Anasti J N, Froehlich J, Flack M R
Abstract excerpt
Separate sites for glycoprotein hormone receptor binding and signal transduction have yet to be elucidated. In general, certain peptide regions are thought to be critical for receptor binding, whereas the oligosacharides are thought to be important for signal transduction. Using site-directed mutagenesis of FSH, we made selective amino acid substitutions and oligosaccharide alterations to try and identify...
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