Article
Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expression.
Molecular and cellular endocrinology - 2 Jan 2007
Ulloa-Aguirre Alfredo, Uribe Aída, Zariñán Teresa, Bustos-Jaimes Ismael, Pérez-Solis Marco A, Dias James A
Abstract excerpt
The human (h) follicle-stimulating hormone receptor (FSHR) belongs to the superfamily of G protein-coupled receptors (GPCRs). This receptor consists of 695 amino acid residues and is preferentially coupled to the G(s) protein. This receptor is highly conserved among species (overall homology, 85%), with a 25-69% homology drop when compared to the human LH and TSH receptors. Although studies in prototypical...
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