Article
Specific roles for the asparagine-linked carbohydrate residues of recombinant human follicle stimulating hormone in receptor binding and signal transduction.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1994
Bishop L A, Robertson D M, Cahir N, Schofield P R
Abstract excerpt
FSH comprises two distinct subunits, both of which contain asparagine-linked carbohydrate residues, located at positions 52 and 78 on the alpha-subunit and positions 7 and 24 on the beta-subunit. These carbohydrate chains have been shown to regulate the biological activity of FSH, including signa...
Topics
- Animals
- Asparagine
- Base Sequence
- Blotting, Southern
- CHO Cells
- Carbohydrates
- Cricetinae
- DNA
- Follicle Stimulating Hormone
- Glycosylation
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Receptors, FSH
- Recombinant Proteins
- Signal Transduction
- Transfection