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Article

Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta.

The Journal of biological chemistry - 16 May 2003

Tan Lujian, Peng Haibing, Osaki Makoto, Choy Bob K, Auron Philip E, Sandell Linda J, Goldring Mary B

Abstract excerpt

Following induction and activation of the early growth response (Egr)-1 transcription factor in human chondrocytes, interleukin-1beta (IL-1beta) suppresses the expression of the type II collagen gene (COL2A1), associated with induction of Egr-1 binding activity in nuclear extracts. The COL2A1 pro...

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Source

Identifiers

PMID: 12637574
DOI: 10.1074/jbc.M301676200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12637574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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