TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence.

doi:10.1016/0092-8674(90)90807-q

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence.

Cell - 20 Apr 1990

Kerr L D, Miller D B, Matrisian L M

Abstract excerpt

Transforming growth factor beta 1 (TGF-beta 1) inhibits the growth factor and oncogene induction of transin/stromelysin, a secreted matrix-degrading metalloprotease. We demonstrate that a 10 bp element in the transin promoter is required for the TGF-beta 1 inhibitory effects and that this sequence is conserved in the promoter regions of several other TGF-beta 1-inhibited genes. The TGF-beta 1 inhibitory element...

Topics

Animals
Base Sequence
Cell Line
Gene Expression
Humans
Matrix Metalloproteinase 3
Metalloendopeptidases
Molecular Sequence Data
Mutation
Neoplasm Proteins
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Promoter Regions, Genetic

Protein Biosynthesis

Protein-Tyrosine Kinases

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-fos

Source

Open in PubMed

Identifiers

PMID: 2110031
DOI: 10.1016/0092-8674(90)90807-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2110031-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence.PMID 2110031Read ↗

c-myc Is a Downstream Target of the Smad PathwaySemantic proximity Read ↗

Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.Semantic proximity Read ↗

The ternary complex factor Net regulates cell migration through inhibition of PAI-1 expression.Semantic proximity Read ↗

Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion.Semantic proximity Read ↗

The FOS Transcription Factor Family Differentially Controls Trophoblast Migration and InvasionSemantic proximity Read ↗

Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1Semantic proximity Read ↗

Expression of Angiopoietin-2 in Endothelial Cells Is Controlled by Positive and Negative Regulatory Promoter ElementsSemantic proximity Read ↗

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoproteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.