Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence.

doi:10.1080/07391102.1992.10507983

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Article

Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence.

Journal of biomolecular structure & dynamics - 1 Jun 1992

Gabb H A, Harris M E, Pandey N B, Marzluff W F, Harvey S C

Abstract excerpt

The 3'-end of histone mRNAs contains a highly conserved sequence motif which is believed to form a 6 base pair stem and a 4 base loop. These sequences are involved in both the efficiency of 3'-end formation and stability of the mature histone mRNA. We have modeled four stem basepairs and the loop...

Topics

Base Sequence
Histones
Models, Molecular
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA, Messenger
Structure-Activity Relationship
X-Ray Diffraction

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