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Article

Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G.

Journal of virology - 1 Jun 2008

Kempf Brian J, Barton David J

Abstract excerpt

Poliovirus (PV) 2A protease (2A(Pro)) cleaves eukaryotic initiation factors 4GI and 4GII (eIF4GI and eIF4GII) within virus-infected cells, effectively halting cap-dependent mRNA translation. PV mRNA, which does not possess a 5' cap, is translated via cap-independent mechanisms within viral protease-modified messenger ribonucleoprotein (mRNP) complexes. In this study, we determined that 2A(Pro) activity was...

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Identifiers

PMID: 18400852
DOI: 10.1128/JVI.01514-07
PMCID: PMC2395153

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