Article

Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells

2019-03-28

Abstract excerpt

Human rhinoviruses express 2 cysteine proteases, 2A and 3C, that are responsible for viral polyprotein processing. Both proteases also suppress host gene expression by inhibiting mRNA transcription, nuclear export and cap-dependent translation. However, the relative contribution that each makes in achieving this goal remains unclear. In this study we have compared both the combined and individual ability of the 2...

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Literature Corpus work: 47aa29e5-11cb-5678-9007-fe38a8e0a102
DOI: 10.1101/591032

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