Article
Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype.
Oncotarget - 7 Feb 2017
Hopkinson Branden M, Klitgaard Marie C, Petersen Ole William, Villadsen René, Rønnov-Jessen Lone, Kim Jiyoung
Abstract excerpt
Understanding human cancer increasingly relies on insight gained from subtype specific comparisons between malignant and non-malignant cells. The most frequent subtype in breast cancer is the luminal. By far the most frequently used model for luminal breast cancer is the iconic estrogen receptor-positive (ERpos) MCF7 cell line. However, luminal specific comparisons have suffered from the lack of a relevant...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- Cell Communication
- Cell Line, Transformed
- Cell Proliferation
- Cell Separation
- Cellular Microenvironment
- Coculture Techniques
- Estradiol
- Female
- Fibroblasts
- Genotype
- Humans