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Article

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

Virology - 1 Dec 1994

Little S J, Riggs N L, Chowers M Y, Fitch N J, Richman D D, Spina C A, Guatelli J C

Abstract excerpt

Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective genomes in pathogenesis is unclear. The hypothesis that such replication-defective genomes might induce downregulation of the cellular receptor for HIV-1 (CD4) was tested. CEM cells were stably transfected with a provirus that contains a mutation in the splice...

Topics

CD4 Antigens
Cell Line
Defective Viruses
Down-Regulation
Gene Products, nef
HIV-1
Mutation
Proviruses
Viral Interference
Virus Replication
nef Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7975260
DOI: 10.1006/viro.1994.1683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7975260-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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