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Article

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

Virology - 1 Dec 1994

Little S J, Riggs N L, Chowers M Y, Fitch N J, Richman D D, Spina C A, Guatelli J C

Abstract excerpt

Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective genomes in pathogenesis is unclear. The hypothesis that such replication-defective genomes might induce downregulation of the cellular receptor for HIV-1 (CD4) was tested. CEM cells were stably transfected with a provirus that contains a mutation in the splice...

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Identifiers

PMID: 7975260
DOI: 10.1006/viro.1994.1683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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