Article
T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Feb 1998
Cucchiarini M, Barcellini-Couget S, Lefebvre J C, Doglio A
Abstract excerpt
Among HIV viral proteins, envelope glycoproteins and Nef have been both suggested to participate in CD4 downregulation during the course of HIV infection. In a previous study, we provided evidence that a mutant form of CD4 that does not bind gp120 was never downregulated in chronically HIV-1- and...
Topics
- CD4 Antigens
- Cell Line
- Down-Regulation
- Gene Products, nef
- HIV
- HIV-1
- HIV-2
- Mutation
- T-Lymphocytes
- Tetradecanoylphorbol Acetate
- nef Gene Products, Human Immunodeficiency Virus