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Article

CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.

Journal of virology - 1 Sept 1996

Chen B K, Gandhi R T, Baltimore D

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected cells. To quantitatively assess the relative contribution of each gene product to the regulation of CD4 during HIV infection of Jurkat T cells and peripheral blood mononuclear cells, we have developed an infectious HIV reporter system which expresses different...

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Identifiers

PMID: 8709227
DOI: 10.1128/JVI.70.9.6044-6053.1996
PMCID: PMC190625

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