Article
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
Journal of virology - 1 Sept 1996
Chen B K, Gandhi R T, Baltimore D
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected cells. To quantitatively assess the relative contribution of each gene product to the regulation of CD4 during HIV infection of Jurkat T cells...
Topics
- Alkaline Phosphatase
- Antigens, CD
- Base Sequence
- Blotting, Western
- CD4 Antigens
- Cell Line
- Clone Cells
- DNA Polymerase I
- DNA Primers
- DNA, Viral
- Female
- Flow Cytometry
- Gene Expression Regulation, Viral
- Genes, env
- Genes, nef
- Genes, vpu
- Genotype
- HIV-1