Is a low serum concentration of alpha 1-antitrypsin associated with an increased susceptibility for byssinosis in cotton mill workers? Considerations regarding analytical quality requirements and economical consequences.

doi:10.3109/03009739309179324

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Article

Is a low serum concentration of alpha 1-antitrypsin associated with an increased susceptibility for byssinosis in cotton mill workers? Considerations regarding analytical quality requirements and economical consequences.

Upsala journal of medical sciences - 1 Jan 1993

Brandslund I, Lund E D, Sigsgaard T

Abstract excerpt

We have previously demonstrated an association between development of the cotton lung disease byssinosis and endotoxin concentrations in the work environment. Endotoxin has been shown to exert its effects through granulocyte activation and hence release of elastase and other proteases at the bronchoalveolar surface. alpha 1-Antitrypsin is a protease inhibitor, and hence, alpha 1-Antitrypsin concentrations in the...

Topics

Byssinosis
Chemistry, Clinical
Costs and Cost Analysis
Disease Susceptibility
Humans
Models, Theoretical
Occupational Diseases
Osmolar Concentration
Phenotype
Quality Assurance, Health Care

Risk Factors

alpha 1-Antitrypsin

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