Article
A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.
PloS one - 1 Jan 2013
Zhang Ruyang, Zhao Yang, Chu Minjie, Mehta Amar, Wei Yongyue, Liu Yao, Xun Pengcheng, Bai Jianling, Yu Hao, Su Li, Zhang Hongxi, Hu Zhibin, Shen Hongbing, Chen Feng, Christiani David C
Abstract excerpt
BACKGROUND: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood. OBJECTIVE: We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in...
Topics
- Adolescent
- Adult
- Byssinosis
- Endotoxins
- Epistasis, Genetic
- Female
- Forced Expiratory Volume
- Gene Regulatory Networks
- Gene-Environment Interaction
- Genetic Predisposition to Disease