Experimental HIV infection of human lymphoid tissue: correlation of CD4+ T cell depletion and virus syncytium-inducing/non-syncytium-inducing phenotype in histocultures inoculated with laboratory strains and patient isolates of HIV type 1.

Abstract excerpt

It is now apparent that HIV infection leads to a gradual collapse of a complex system of lymphoid tissue. This collapse tends to be associated with a change in virus tropism from macrophages to T lymphocytes, and a change in phenotype from nonsyncytium inducing (NSI) to syncytium inducing (SI). A...

Topics

• Adenoids
• CD4-Positive T-Lymphocytes
• Culture Techniques
• Giant Cells
• HIV Infections
• HIV-1
• Humans
• Infant
• Lymphocyte Depletion
• Lymphoid Tissue
• Palatine Tonsil