The cytopathicity of a simian immunodeficiency virus Mne variant is determined by mutations in Gag and Env.

doi:10.1128/JVI.71.10.7629-7639.1997

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Article

The cytopathicity of a simian immunodeficiency virus Mne variant is determined by mutations in Gag and Env.

Journal of virology - 1 Oct 1997

Kimata J T, Overbaugh J

Abstract excerpt

Previous studies suggested that the rapidly replicating, highly cytopathic, syncytium-inducing (rapid-high/SI) phenotype of simian immunodeficiency virus Mne variants that evolved in macaques inoculated with a slowly replicating, minimally cytopathic, non-syncytium-inducing (slow-low/NSI) molecul...

Topics

Amino Acid Sequence
Animals
CD4-Positive T-Lymphocytes
Cell Line
Cells, Cultured
Chimera
Cloning, Molecular
DNA Primers
Gene Products, env
Gene Products, gag
Genes, env
Genes, gag
Genetic Variation
Giant Cells
Humans
Jurkat Cells
Kinetics
Lymphocytes

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