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Article

Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant.

The Journal of investigative dermatology - 1 Jun 1997

Randazzo B P, Bhat M G, Kesari S, Fraser N W, Brown S M

Abstract excerpt

Modified, non-neurovirulent herpes simplex viruses (HSV) have shown promise for the treatment of brain tumors, including intracranial melanoma. In this report, we show that HSV-1716, an HSV-1 mutant lacking both copies of the gene coding-infected cell protein 34.5 (ICP 34.5), can effectively treat experimental subcutaneous human melanoma in mice. In vitro, HSV-1716 replicated in all 26 human melanoma cell lines...

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Source

Identifiers

PMID: 9182825
DOI: 10.1111/1523-1747.ep12295238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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