Article
Differences in HIV-1 pol sequences from female genital tract and blood during antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2003
De Pasquale Maria Pia, Leigh Brown Andrew J, Uvin Susan Cu, Allega-Ingersoll Jessica, Caliendo Angela M, Sutton Lorraine, Donahue Shannon, D'Aquila Richard T
Abstract excerpt
OBJECTIVE: To determine whether HIV-1 replicates locally in the female genital tract during therapy, and to study whether endocervix is the dominant source of virus in cervicovaginal lavage fluid. DESIGN: Sequence analyses of HIV-1 pol were performed from cervicovaginal secretions and blood plasma of HIV-infected women failing antiretroviral therapy with detectable viral load in both compartments, as well as from...
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