Article
Determination of human immunodeficiency virus RNA in plasma and cellular viral DNA genotypic zidovudine resistance and viral load during zidovudine-didanosine combination therapy.
Journal of virology - 1 Jun 1995
Holodniy M, Mole L, Margolis D, Moss J, Dong H, Boyer E, Urdea M, Kolberg J, Eastman S
Abstract excerpt
Eleven human immunodeficiency virus (HIV)-infected subjects on long-term zidovudine (ZDV) therapy had didanosine (ddI) added to their antiretroviral regimen. HIV RNA in plasma was quantitated by branched-DNA signal amplification assay. Peripheral blood mononuclear cell (PBMC) HIV viral DNA was quantitated by PCR. The relative amounts of wild-type (WT) sequence, ddI resistance-associated codon changes (reverse...
Topics
- Base Sequence
- DNA, Viral
- Didanosine
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Genotype
- HIV
- HIV Infections
- Humans
- Molecular Sequence Data
- RNA, Viral