Article
Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine.
Journal of clinical microbiology - 1 Feb 1995
Frenkel L M, Wagner L E, Atwood S M, Cummins T J, Dewhurst S
Abstract excerpt
The effectiveness of antiretroviral therapy may be limited by the development of human immunodeficiency virus type 1 (HIV-1) resistance. Monitoring for resistance will perhaps allow changes in therapy prior to deterioration in the patient's clinical or immunologic status. Our objective was to dev...
Topics
- Base Sequence
- DNA Ligases
- DNA Primers
- DNA Probes
- DNA, Viral
- Didanosine
- Drug Resistance, Microbial
- Evaluation Studies as Topic
- Genes, pol
- HIV Infections
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sensitivity and Specificity
- Time Factors
- Virology