Article
TP53 tumor suppressor gene and skin carcinogenesis.
The Journal of investigative dermatology - 1 Nov 1994
Basset-Séguin N, Molès J P, Mils V, Dereure O, Guilhou J J
Abstract excerpt
The tumor suppressor gene TP53 encodes for a nuclear phosphoprotein involved in the control of cell proliferation, particularly in stressed cells. TP53 gene mutations are the most frequent genetic event found in human cancers. Most mutations locate in the highly conserved domains of the gene. Their localizations vary according to the tissue and tumor type, but define some hot spot regions that may have a certain...
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