TP53 tumor suppressor gene and skin carcinogenesis.

doi:10.1111/1523-1747.ep12399372

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Article

TP53 tumor suppressor gene and skin carcinogenesis.

The Journal of investigative dermatology - 1 Nov 1994

Basset-Séguin N, Molès J P, Mils V, Dereure O, Guilhou J J

Abstract excerpt

The tumor suppressor gene TP53 encodes for a nuclear phosphoprotein involved in the control of cell proliferation, particularly in stressed cells. TP53 gene mutations are the most frequent genetic event found in human cancers. Most mutations locate in the highly conserved domains of the gene. The...

Topics

Genes, Tumor Suppressor
Genes, p53
Genetic Techniques
Humans
Melanoma
Mutation
Neoplasms
Skin Neoplasms
Tumor Suppressor Protein p53

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