Article
TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.
Oncology reports - 1 Oct 2017
Monti Paola, Ghiorzo Paola, Menichini Paola, Foggetti Giorgia, Queirolo Paola, Izzotti Alberto, Fronza Gilberto
Abstract excerpt
In contrast to TP53, cancer development is rarely associated with mutations in the TP63 and TP73 genes. Recently, next generation sequencing analysis revealed that TP63 mutations are frequent, specifically in cutaneous melanomas. Cutaneous melanoma represents 4% of skin cancers but it is responsible for 80% of skin cancer related deaths. In the present study, we first determined whether all three members of the...
Topics
- Carcinogenesis
- Humans
- Melanoma
- Molecular Epidemiology
- Mutation
- Neoplasms, Radiation-Induced
- Skin Neoplasms
- Transcription Factors
- Tumor Protein p73
- Tumor Suppressor Protein p53