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Article

Roles of the transcription factor p53 in keratinocyte carcinomas.

The British journal of dermatology - 1 May 2006

Brash D E

Abstract excerpt

The transcription factor p53 is mutated in most keratinocyte carcinomas (nonmelanoma skin cancers). In these tumours, the gene bears the trace of its mutagen, sunlight. Sunlight-induced p53 mutations are also seen in skin precancers and even sun-exposed skin, which harbours thousands of p53-mutant keratinocyte clones. Normal p53 is upregulated by sunlight exposure, after which it acts as a tumour suppressor in...

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Source

Identifiers

PMID: 16712710
DOI: 10.1111/j.1365-2133.2006.07230.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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