Article
Participation of lysine 516 and phenylalanine 530 of diphtheria toxin in receptor recognition.
The Journal of biological chemistry - 18 Nov 1994
Shen W H, Choe S, Eisenberg D, Collier R J
Abstract excerpt
To identify amino acid residues within diphtheria toxin that participate in receptor recognition, we made alanine replacements for each of 12 solvent-accessible residues within a loop (residues 516-530) of the toxin's R domain, which prominently extends from the main surface of the domain. Amino...
Topics
- Amino Acid Sequence
- Animals
- Cell Survival
- Chlorocebus aethiops
- Diphtheria Toxin
- Heparin-binding EGF-like Growth Factor
- Intercellular Signaling Peptides and Proteins
- Lysine
- Molecular Sequence Data
- Mutation
- Phenylalanine
- Receptors, Cell Surface
- Vero Cells