Article
Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.
The Biochemical journal - 15 Apr 2008
Chen Jun, Deng Fan, Li Jun, Wang Q Jane
Abstract excerpt
The PKD (protein kinase D) family are novel DAG (diacylglycerol) receptors. The twin C1 domains of PKD, designated C1a and C1b, have been shown to bind DAG or phorbol esters. However, their ligand-binding activities and selectivities have not been fully characterized. Here, binding activities of isolated C1a, C1b and intact C1a-C1b domains to DAG and phorbol esters were analysed. The isolated C1b domains of PKD...
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