Article
Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation.
Invasion & metastasis - 1 Jan 1993
Adatia R, Albini A, Colacci A, De Giovanni C, Nanni P, Giunciuglio D, Parodi S, Grilli S, Perocco P
Abstract excerpt
1,2-Dibromoethane (DBE), which can act as initiating agent, is capable of inducing a malignant phenotype in BALB/c 3T3 cells. Cells transformed with a single noncytotoxic dose formed more progressive tumors in vivo. Almost all animals (95%) receiving the inoculum of two different transformed clon...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Chemotaxis
- Dose-Response Relationship, Drug
- Ethylene Dibromide
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Invasiveness
- Neoplasms, Experimental
- Phenotype
- Time Factors