Neoplastic transformation of BALB/3T3 cells by metals and the quest for induction of a metastatic phenotype.

doi:10.1007/BF02917291

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Article

Neoplastic transformation of BALB/3T3 cells by metals and the quest for induction of a metastatic phenotype.

Biological trace element research - 1 Jan 2000

Saffiotti U, Bertolero F

Abstract excerpt

In the mouse embryo cell line BALB/3T3 Clone A31-1-1, dose-dependent morphologic neoplastic transformation was obtained with NaAsO2, Na2HAsO4, CdCl2, and K2CrO4. Cellular uptake was four fold higher for As3+ than for As5+, and As5- was metabolized to As3+ in cytosol. Cytotoxicity and transformati...

Topics

Animals
Arsenates
Arsenic
Arsenites
Cadmium
Cadmium Chloride
Cell Survival
Cell Transformation, Neoplastic
Chromates
Metals
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Phenotype
Potassium Compounds
Sodium Compounds

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