Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model.

doi:10.1111/j.1365-2958.1994.tb01057.x

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Article

Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model.

Molecular microbiology - 1 Jun 1994

Moffat J F, Edelstein P H, Regula D P, Cirillo J D, Tompkins L S

Abstract excerpt

To determine the effects, if any, of the Zn-metalloprotease on virulence of Legionella pneumophila infection, an isogenic mutant deficient in protease (encoded by the proA gene) was tested in an Acanthamoeba cell model, in guinea-pig macrophages, and in a guinea-pig pneumonia model. The cloned pr...

Topics

Acanthamoeba
Animals
Guinea Pigs
Legionella pneumophila
Legionnaires' Disease
Lung
Macrophages
Metalloendopeptidases
Mutation
Pneumonia
Virulence

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