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Article

An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity.

Molecular microbiology - 1 Jun 1992

Tang C M, Cohen J, Holden D W

Abstract excerpt

Invasive pulmonary aspergillosis, usually caused by Aspergillus fumigatus, is a life-threatening condition of immunosuppressed patients. We have created a mutant strain of this fungus that lacks an extracellular alkaline protease (AFAlp). This was accomplished by transformation of A. fumigatus with a plasmid containing a selectable marker for hygromycin B resistance, and a 504 bp segment of the AFAlp gene,...

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PMID: 1495393
DOI: 10.1111/j.1365-2958.1992.tb00891.x

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SDS

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