Article
Cloning and disruption of the gene encoding an extracellular metalloprotease of Aspergillus fumigatus.
Molecular microbiology - 1 Dec 1994
Jaton-Ogay K, Paris S, Huerre M, Quadroni M, Falchetto R, Togni G, Latgé J P, Monod M
Abstract excerpt
Aspergillus fumigatus secretes a serine alkaline protease (ALP) and a metalloprotease (MEP) when the fungus is cultivated in the presence of collagen as sole nitrogen and carbon source. The gene encoding ALP was isolated and characterized previously. We report here the cloning and the sequencing...
Topics
- Amino Acid Sequence
- Animals
- Aspergillosis
- Aspergillus fumigatus
- Base Sequence
- Cloning, Molecular
- Collagenases
- DNA, Complementary
- DNA, Fungal
- Genes, Fungal
- Lung Diseases, Fungal
- Male
- Metalloendopeptidases
- Mice
- Molecular Sequence Data
- Mutation
- Plasmids
- Restriction Mapping