extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.

doi:10.1016/0092-8674(90)90212-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.

Cell - 6 Apr 1990

Ellis H M, Spann D R, Posakony J W

Abstract excerpt

The function of the extramacrochaetae (emc) gene is required to establish the normal spatial pattern of adult sensory organs in Drosophila. emc acts to suppress sensory organ development in certain regions of the body surface, apparently by antagonizing the function of the achaete and scute genes of the achaetescute complex (AS.C). We have found that emc encodes a novel member of the helix-loop-helix (HLH) family...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Cloning, Molecular
DNA
DNA Transposable Elements
DNA-Binding Proteins
Drosophila
Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Nonmammalian

Gene Expression Regulation

Genes, Regulator

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 1690604
DOI: 10.1016/0092-8674(90)90212-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690604-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.PMID 1690604Read ↗

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.Semantic proximity Read ↗

Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.Semantic proximity Read ↗

The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development.Semantic proximity Read ↗

The extramacrochaetae gene provides information for sensory organ patterning.Semantic proximity Read ↗

emc has a role in dorsal appendage fate formation in Drosophila oogenesis.Semantic proximity Read ↗

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.Semantic proximity Read ↗

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons.Semantic proximity Read ↗

The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.Semantic proximity Read ↗

The genetics of the Drosophila achaete-scute gene complex: a historical appraisal.Semantic proximity Read ↗

The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.