Article
Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.
Genes & development - 1 Dec 1992
Van Doren M, Powell P A, Pasternak D, Singson A, Posakony J W
Abstract excerpt
The spatially restricted activities of achaete (ac) and scute (sc) are thought to define proneural clusters of potential sensory organ precursor cells in the imaginal discs of Drosophila. These genes encode transcriptional regulators of the basic helix-loop-helix (bHLH) class. We have found that direct, positive transcriptional autoregulation by the ac protein and cross-regulation by sc are essential for...
Topics
- Animals
- Binding Sites
- Drosophila
- Gene Expression Regulation
- Genes, Insect
- Mutation
- Phenotype
- Promoter Regions, Genetic
- Transfection