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Article

Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.

PLoS biology - 1 Apr 2018

Masoudi Neda, Tavazoie Saeed, Glenwinkel Lori, Ryu Leesun, Kim Kyuhyung, Hobert Oliver

Abstract excerpt

Proneural genes are among the most early-acting genes in nervous system development, instructing blast cells to commit to a neuronal fate. Drosophila Atonal and Achaete-Scute complex (AS-C) genes, as well as their vertebrate orthologs, are basic helix-loop-helix (bHLH) transcription factors with such proneural activity. We show here that a C. elegans AS-C homolog, hlh-4, functions in a fundamentally different...

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Identifiers

PMID: 29672507
DOI: 10.1371/journal.pbio.2004979
PMCID: PMC5908064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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