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The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.

Cell - 6 Apr 1990

Garrell J, Modolell J

Abstract excerpt

The Drosophila extramacrochaetae (emc) locus participates in sensory organ patterning by antagonizing, in a mechanistically unknown way, the neurogenic activity of the achaete-scute complex (AS-C). Our cloning of emc DNA and molecular mapping of emc mutations have identified a transcription unit as the most likely candidate for the emc function. It encodes a protein that has a dimerizing helix-loop-helix (HLH)...

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Identifiers

PMID: 1690605
DOI: 10.1016/0092-8674(90)90213-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.PMID 1690605Read ↗

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.Semantic proximity Read ↗

Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.Semantic proximity Read ↗

The extramacrochaetae gene provides information for sensory organ patterning.Semantic proximity Read ↗

The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development.Semantic proximity Read ↗

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.Semantic proximity Read ↗

The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene.Semantic proximity Read ↗

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.Semantic proximity Read ↗

HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons.Semantic proximity Read ↗

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