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Article

Sequence and structural elements critical for U8 snRNP function in Xenopus oocytes are evolutionarily conserved.

Genes & development - 15 Sept 1994

Peculis B A, Steitz J A

Abstract excerpt

We have generated mutants in Xenopus U8 RNA, a nucleolar snRNA required for the maturation of 5.8S and 28S rRNAs, to identify sequences and structural domains essential for RNA stability, particle assembly, and function of the U8 RNP. Activity of the mutants was assayed by microinjection of in vitro-synthesized U8 RNAs into the cytoplasm of Xenopus oocytes. Most of the mutant RNAs were stable, bound fibrillarin,...

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Identifiers

PMID: 7958892
DOI: 10.1101/gad.8.18.2241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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