Sequence and structural elements critical for U8 snRNP function in Xenopus oocytes are evolutionarily conserved.

doi:10.1101/gad.8.18.2241

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Article

Sequence and structural elements critical for U8 snRNP function in Xenopus oocytes are evolutionarily conserved.

Genes & development - 15 Sept 1994

Peculis B A, Steitz J A

Abstract excerpt

We have generated mutants in Xenopus U8 RNA, a nucleolar snRNA required for the maturation of 5.8S and 28S rRNAs, to identify sequences and structural domains essential for RNA stability, particle assembly, and function of the U8 RNP. Activity of the mutants was assayed by microinjection of in vi...

Topics

Animals
Base Sequence
Biological Evolution
Chromosomal Proteins, Non-Histone
Conserved Sequence
Female
Methylation
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nucleic Acid Conformation
Oocytes
RNA Caps
RNA Precursors
RNA Processing, Post-Transcriptional
RNA, Small Nuclear
Ribonucleoproteins, Small Nuclear
Xenopus

Source

Open in PubMed

Identifiers

PMID: 7958892
DOI: 10.1101/gad.8.18.2241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7958892-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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