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Article

Insulin-like growth factor 2 cannot be linked to a familial form of Beckwith-Wiedemann syndrome.

European journal of pediatrics - 1 Aug 1994

Nyström A, Hedborg F, Ohlsson R

Abstract excerpt

The Beckwith-Wiedemann syndrome (BWS) is characterised by congenital malformations and organomegaly associated with an increased risk for development of childhood neoplasms. Both a sporadic and a familial form have been described in the literature. It has been suggested that duplications or rearrangements of the short arm of chromosome 11 (11p15.5) underlie the aetiology of the disease. This region of chromosome...

Topics

Alleles
Beckwith-Wiedemann Syndrome
Chromosomes, Human, Pair 11
Fathers
Female
Genetic Linkage
Humans
Insulin-Like Growth Factor II
Male
Pedigree
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7957404
DOI: 10.1007/BF02190661

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7957404-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Insulin-like growth factor 2 cannot be linked to a familial form of Beckwith-Wiedemann syndrome.PMID 7957404Read ↗

Molecular investigation of familial Beckwith-Wiedemann syndrome: a model for paternal imprinting.Semantic proximity Read ↗

Molecular biology of Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.Semantic proximity Read ↗

Novel deletion in 11p15.5 imprinting center region 1 in a patient with Beckwith-Wiedemann syndrome provides insight into distal enhancer regulation and tumorigenesis.Semantic proximity Read ↗

Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Semantic proximity Read ↗

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Paternally Inherited Submicroscopic Duplication at 11p15.5 Implicates Insulin-like Growth Factor II in Overgrowth and Wilms' TumorigenesisSemantic proximity Read ↗

Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 GeneSemantic proximity Read ↗

Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.Semantic proximity Read ↗

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