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Article

Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome.

Human molecular genetics - 1 Aug 1994

Reik W, Brown K W, Slatter R E, Sartori P, Elliott M, Maher E R

Abstract excerpt

Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth syndrome with associated embryonal tumours. Most BWS cases are sporadic but familial cases occur in 15% of patients and in these there is linkage to chromosome 11p15. In addition, a small number of patients have cytogenetic abnormalities involving chromosome 11p15. Approximately 20% of sporadic BWS patients have uniparental paternal disomy (UPD) of...

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Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7987305
DOI: 10.1093/hmg/3.8.1297

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome.PMID 7987305Read ↗

Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Semantic proximity Read ↗

Imprinting mutations in the Beckwith—Wiedemann syndrome suggested by an altered imprinting pattern in the <i>IGF2–H19</i> domainSemantic proximity Read ↗

Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.Semantic proximity Read ↗

Molecular investigation of familial Beckwith-Wiedemann syndrome: a model for paternal imprinting.Semantic proximity Read ↗

Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.Semantic proximity Read ↗

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.Semantic proximity Read ↗

Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor.Semantic proximity Read ↗

Molecular biology of Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and CancerSemantic proximity Read ↗

Imprinting status of 11p15 genes in Beckwith-Wiedemann syndrome patients with CDKN1C mutations.Semantic proximity Read ↗

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