Article
Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.
Nature genetics - 1 Oct 1993
Weksberg R, Shen D R, Fei Y L, Song Q L, Squire J
Abstract excerpt
To study insulin-like growth factor 2 (IGF2) imprinting in BWS (Beckwith-Wiedemann syndrome, an overgrowth syndrome associated with Wilms and other embryonal tumours), we examined allele-specific expression using an Apal polymorphism in the 3' untranslated region of IGF2. Four of six BWS fibroblast strains demonstrated biallelic expression, as did the tongue tissue from one of these patients. Paternal...
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