Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.

doi:10.1038/ng1093-143

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Article

Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome.

Nature genetics - 1 Oct 1993

Weksberg R, Shen D R, Fei Y L, Song Q L, Squire J

Abstract excerpt

To study insulin-like growth factor 2 (IGF2) imprinting in BWS (Beckwith-Wiedemann syndrome, an overgrowth syndrome associated with Wilms and other embryonal tumours), we examined allele-specific expression using an Apal polymorphism in the 3' untranslated region of IGF2. Four of six BWS fibrobla...

Topics

Adolescent
Adult
Alleles
Beckwith-Wiedemann Syndrome
Cell Line
Child
DNA
Female
Gene Expression Regulation
Heterozygote
Humans
Insulin-Like Growth Factor II
Lymphocytes
Male

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