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Article

Mouse Mx2 gene: organization, mRNA expression and the role of the interferon-response promoter in its regulation.

Gene - 13 Mar 2003

Asano Atsushi, Jin Hee Kyung, Watanabe Tomomasa

Abstract excerpt

Mx is an interferon (IFN)-inducible intracellular protein found in various vertebrates that mediates resistance against negative-strand RNA viruses. We have demonstrated previously that feral mouse strains are able to express a functional Mx2 mRNA, while that of the inbred laboratory strains was non-functional because of a single nucleotide insertion in the open reading frame, and under the detectable level. In...

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PMID: 12657472
DOI: 10.1016/s0378-1119(03)00428-1

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SPR

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