Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.

doi:10.1016/0041-008x(92)90220-m

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Article

Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.

Toxicology and applied pharmacology - 1 Nov 1992

de Morais S M, Chow S Y, Wells P G

Abstract excerpt

Acetaminophen is eliminated primarily by glucuronidation, thereby avoiding cytochrome P450-catalyzed bioactivation to a toxic reactive intermediate. Previous studies have shown that UDP-glucuronosyltransferase-deficient Gunn rats are more susceptible to acetaminophen toxicity than normal Wistar c...

Topics

Acetaminophen
Acetylcysteine
Alanine Transaminase
Animals
Biotransformation
Glucosyltransferases
Heterozygote
Jaundice
Male
Metabolism, Inborn Errors
Phenotype
Rats
Rats, Inbred Strains

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