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Article

p53 deletion as a genetic marker in urothelial tumor by fluorescence in situ hybridization.

Cancer research - 1 Dec 1994

Matsuyama H, Pan Y, Mahdy E A, Malmström P U, Hedrum A, Uhlen M, Busch C, Hirano T, Auer G, Tribukait B

Abstract excerpt

In order to investigate the significance of p53 deletion, 42 specimens of transitional cell carcinoma were analyzed by interphase cytogenetics with a fluorescence in situ hybridization technique and compared with clinicopathological and cytochemical parameters. In total, 27 (64%) and 16 (38%) specimens demonstrated p53 deletion and overexpression, respectively. The p53 deletion was significantly correlated with...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell
Female
Gene Deletion
Genes, p53
Genetic Markers
Humans
In Situ Hybridization, Fluorescence
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 7954445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7954445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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