Article
p53 deletion as a genetic marker in urothelial tumor by fluorescence in situ hybridization.
Cancer research - 1 Dec 1994
Matsuyama H, Pan Y, Mahdy E A, Malmström P U, Hedrum A, Uhlen M, Busch C, Hirano T, Auer G, Tribukait B
Abstract excerpt
In order to investigate the significance of p53 deletion, 42 specimens of transitional cell carcinoma were analyzed by interphase cytogenetics with a fluorescence in situ hybridization technique and compared with clinicopathological and cytochemical parameters. In total, 27 (64%) and 16 (38%) specimens demonstrated p53 deletion and overexpression, respectively. The p53 deletion was significantly correlated with...
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